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In addition, in AD brain both 20S and 19S proteasomal complexes are targets of ox-PTMs, including the formation of HNE adducts, carbonylation, S -glutathionylation, glycoxidation, as well as ADP-ribosylation and phosphorylation (346, 355, 356)

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Interestingly, bile acids have a direct role in promoting gallbladder filling by signaling directly via TGR5 or by stimulating ileal synthesis and release of FGF15/19, a polypeptide hormone that induces gallbladder relaxation

The primary concern with "too much" of any antioxidant is the disruption of the bodys natural redox balance

[Google Scholar] 11.Berlin I, Sad S, Spreux-Varoquaux O, Launay JM, Olivares R, Millet V, Lecrubier Y, Puech AJ