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12) How should covert HE be defined and diagnosed

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Senescence is associated with TRPC3 downregulation, which increases mitochondrial Ca 2+ uptake, mitochondrial depolarization, and ROS production and alters mitochondrial metabolism, thereby promoting the protumourigenic effects of senescence [318]

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Education A structured educational intervention has been reported to improve patient adherence to prophylactic therapy and reduce readmission with OHE [289]

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