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PMID: 22462011

These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods

550 In Phase II trials (KARDIA-1), zilebesiran reduced systolic blood pressure in all treated patients, with effects lasting 6 months, opening new possibilities for NADs use in treating hypertension and CVDs