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Date check (most reliable) Simplest method: If it's been more than 30 days since reconstitution, discard regardless of appearance

Washington Doherty, Nancy E
The results of multivariate logistic regression showed that intervention can reduce the risk of the 28-day mortality rate by 76% (odds ratio: 0.233, p-value: 0.010, 95% CI: 0.077 to 0.708) (Table 3)

Some users run it continuously for 6 months without reported issues, but this exceeds the controlled evidence base
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