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This calcium increase in the post synaptic cell activates the phosphorylation of kinases and more release of Ca 2+ from ryanodine receptors (RyRs) in endoplasmic reticulum (ER) through a calcium-induced calcium-release (CICR) thus amplifying calcium signaling

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Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing macrophage function

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