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To those with gluten intolerance
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The results showed that a genetic variant in the GRIK2 gene was more common in people with ME/CFS, and that the gene expression for that gene was decreased by 10-fold in patients compared to controls.[ref] Related article: Glutamate receptor gene variants Circadian clock gene, NPAS2: The study mentioned above also identified a circadian clock gene variant as differentially expressed (10-fold difference) and a variant in the gene as increasing susceptibility to ME/CFS.[ref] Rare mutations: A 2025 Stanford study using the HEAL2 deep learning framework analyzed whole genome sequences from 1,075 ME/CFS patients
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al
Reactive oxidative species (ROS) are highly active molecules containing oxygen and are natural byproducts of normal metabolism
