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These results further support a significant negative causal relationship between mtDNA-CN and DKA, while the causal effect of DKA on mtDNA-CN is not significant

For instance, the inhibition of fatty acid binding proteins (FABPs) affects mitochondrial integrity, leading to the release of mitochondrial DNA and the initiation of cGAS/STING-dependent type I interferon signaling

The treatment of allergic disease is a good example of this approach, where integrative and holistic medicine involves not merely suppressing the troublesome symptoms (for example, itchy skin), but tries to determine the underlying immune imbalances that lead to the allergic symptoms

doi: 10.2741/2759 124 JianqinZChuxuanWLiGGuanhuaDXuemeiQ
Conversely, poorly optimized combinations, such as coupling Nrf2 activators with aggressive systemic iron chelators, might inadvertently exacerbate the cytosolic iron pseudo-starvation signal, potentially overriding the benefits of either drug and precipitating toxicity
