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The PERK-ATF4-CHOP pathway is a central signaling cascade activated in response to ER stress, serving as the cells primary reaction to dysfunction and playing a crucial role in cellular survival

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All of this data has clinical relevance: Polonikov , studying 4 cases of moderate to severe COVID-19, found that while the three patients with high normal plasma glutathione levels recovered quickly, the one with low glutathione levels, high plasma ROSs and ROS / GSH ratio was suffering from the most severe disease and, at the time of publication, was still ill