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Neuron 88 , 207219 (2015)

[DOI] [PubMed] [Google Scholar] 27.Yi Y.W., Kang H.J., Bae I

This is a relatively large number of cysteines for a protein of this size (3.9% vs 2.3% average cysteine content of human proteins) 17

Nevertheless, pharmacokinetic data indicate that oral methotrexate can cause a decrease in red and white blood cell and platelet counts and can also cause severe liver damage, diarrhea, and stomach irritation, as dose-related drug-induced side effects