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NNT is therefore essential in the regulation of mitochondrial NADPH production and glutathione redox state (E GSH ), and hence in cell antioxidant defences [18, 19, 21,22,23,24]

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We consider their application for early and accurate diagnosis, in the context of recent proposals of staging systems for PD

To this end, we expressed exogenous NRF2-FL in Hs578 cells and analyzed the transcriptome after 8 h of Cyss deprivation in comparison to cells grown in the presence of Cyss and to cells expressing GFP as a control and treated in the same manner (Fig

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity