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This unique feature circumvents the limitations of antioxidants such as sodium pyruvate, a direct H 2 O 2 scavenger, and N-acetylcysteine (NAC), which indirectly reduce H 2 O 2 by replenishing glutathione for GPx-mediated detoxification, both of which require high doses for efficacy (250 mg/kg and 200 mg/kg, respectively)

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Notably, the stability and optical properties of the ferri-Tiron complex are strongly dependent on the pH of the reaction environment [27]

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10 H 17 N 3 O 6 S Reduced Glutathione (GSH) is a biological antioxidant that helps protect cells from reactive oxygen species such as free radicals and peroxides