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V.SpringborgJ
First, mice receiving moringin pretreatment (16.4 mol/kg glucomoringin +5 L myrosinase daily for a week before EAE induction and 28 days after EAE induction) exhibited increased expression of Nrf2, reduced cell apoptosis, and suppressed aberrant Wnt- -catenin signaling in EAE mice (93)
Scott and Winzor, 2015)
Therefore, an amplification loop sustaining mitochondrial dysfunction in APAP-mediated hepatotoxicity has been suggested, involving two hits
& Stoecklin, G
