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When the copper ion content is high in liver cells, the ATOX1 binds with excess copper ions and transports them to the N-terminal metal-binding region of ATP7B, which is then excreted through the bile duct membrane

Front Psychiatry 11:799

The prolonged form of fatigue exists with same symptoms (acute symptoms) but may run for longer duration i.e., 30 days to 6 months (Esposito et al

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glutathione supplementation corrected copper-induced oocyte damage (Ren et al., 2023)
