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Description
showed that the thiol group in GSH can be oxidized directly by copper (Cu 2+ ) which led to the decrease of GSH level intracellularly and thus interfere with glutathione peroxidase function in neutralizing H 2 O 2 to water [34, 35]
Genomics 11, 537561

This detoxification system works continuously but faces increasing challenges in our modern world

Photoreceptor-targeted extracellular vesicles-mediated delivery of cul7 sirna for retinal degeneration therapy

doi: 10.1098/rstb.2014.0121
