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Microbiota changes also impact the host immunity and epithelial function through metabolite regulation
THF either enters the 5-CH3-THF pool for the methylation cycle via methylenetetrahydrofolate reductase (MTHFR) or is utilized in the purine cycle for DNA/RNA biosynthesis (Oosterom et al
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utilized human induced pluripotent stem cells which were derived from cortical spheroids (hCS) to illustrate how PSEN1 mutations affect neurological development, contributing to fAD advancement [43]
