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Among patients with stable coronary artery disease (n = 2235) (Senthong et al., 2016), heart failure (n = 720) (Tang et al., 2014) and peripheral artery disease (PAD) (n = 935) (Senthong et al., 2016), elevated TMAO levels could predict 5-year mortality and increased plasma TMAO levels were respectively associated with a 4-fold, 3.4-fold and 2.7-fold increased mortality risk

Human data on piperlongumine are missing, apart from a single clinical study in Japanese women which showed that Piper longum extract increased peripheral blood flow and skin temperature after cold stress [99]

doi: 10.1016/j.pneurobio.2019.03.001 71 BianchiVELocatelliV

Carnitine is a non-essential amino acid, which our body naturally creates and stores in the skeletal muscles, heart and brain

Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial