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The molecular mechanisms by which IGF-1/IGF-1R signaling meticulously regulates PCa development and progression have been investigated in detail (shown in Figure 1 and Figure 2)
2013;2:e28
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The beta cell-specific genetic risk score, composed of 30 beta cell function SNPs, was strongly associated with increasing beta cell dysfunction from prediabetes to diabetes, reinforcing the idea that beta cell failure is a primary driver of disease progression
The Arabidopsis vtc2/vtc5 double mutants, which are unable to synthesize ascorbate, are not viable (Dowdle et al ., 2007)
