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Another study found that TMP via intracranial administration was able to prevent the cognitive behavioral phenotype of diabetes by modulating the SIRT1/Nrf2/HO-1 pathway, increasing the concentrations of GSH and SOD, as well as decreasing the content of mitochondrial DNA in the hippocampus of STZ-AD mice (119)

Furthermore, mice expressing the same variant demonstrated autistic-like behavior (e.g., impaired social behavior, decreased exploratory behavior, increased anxiety) and reduced BDNF release [178]

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The core part of this work has now been published in the