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Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion

Nguyen TT, Cao N, Short JL, White PJ

The increase of insulin sensitivity in muscle, adipocytes and liver depends more on GSNO than on pure NO [72,73]

PQ (Methyl viologen dichloride hydrate/paraquat, Sigma-Aldrich, #856177) was always freshly prepared and first adjusted to a 1 M stock in H 2 O, which was further diluted for the treatment

Inflammatory damage to the vascular endothelium, which can be partly mediated by excessive iNOS-derived NO, also results in decreased vascular bioavailability of eNOS-derived NO due to impaired eNOS function [[138], [139], [140]]