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In addition, TMAO induced several pro-atherogenic inflammatory proteins including cyclooxygenase 2, E-selectin, IL-6 and intracellular adhesion molecule 1 by activating NF-B (Seldin et al., 2016)
Although most evidence remains correlative, the consistent findings across ethnically and geographically diverse cohorts underscore the clinical relevance of TMAO as a biomarker and potential therapeutic target in cardiovascular disease
Cole JL
Khodir SA, Al-Gholam MA, Salem HR
