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As these proteins pump H + ions into the acidic vesicles, more CQ diffuses from the cytoplasm into the lysosome following a pH gradient, causing an irreversible CQ accumulation, and increasing pH by trapping H + ions [266]

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The body relies on the sulfation pathway (which requires bioavailable sulfur) to properly metabolize and clear histamine from the bloodstream

By using this sublingual method, some research suggests it could potentially support more rapid absorption of the nutrient through mucosal tissues and bypass digestion

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