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[49] Post-marketing worldwide reports in patients receiving oral ketoconazole have included rare cases of paresthesias, and signs of increased intracranial pressure including bulging fontanelles and papilledema

Therefore, gaining insight into the causal factors that contribute to the underlying cellular and molecular changes during ageing will be instrumental in the development of therapeutic interventions

10.1016/S1360-1385(00)01601-0 43 EdwardsR.DixonR