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Pediatr Res 46 : 715721 Esworthy RS, Aranda R, Martin MG, Doroshow JH, Binder SW, Chu FF 2001 Mice with combined disruption of Gpx1 and Gpx2 genes have colitis

Rodents and human GCLC promoter regions share similar regulatory mechanisms

1921 As a result, methods to increase GSH availability in disease models have been limited to global provision of cell-permeable GSH esters or GSH precursors, which require functional GSH synthesis and can act as antioxidants on their own