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The field needs validated, in vivocompatible flux sensors (O 2 , H 2 O 2 , NO/ONOO ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, m, pH) to disambiguate signalling pulses from damage plateaus

Dnmt3a moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts

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Given the important role of neuroinflammation in TBI previously discussed and the recent studies that have revealed the powerful effects of microglial depletion strategies on modulating neuroinflammation after TBI, it will be critical to fully characterize the acute and chronic neuroinflammatory responses in a model organism that allows for rapid longitudinal and genetic studies (144148)