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Fibroblasts derived from these CIPO-LIG3 patients exhibit multiple hallmarks of mitochondrial impairment: abnormal cristae and swollen mitochondria with increased average area, as observed with transmission electron microscopy, as well as reduced uncoupled oxygen consumption and decreased ATP levels

ACS Omega 7(26):2281822824 Fernandez M, Urvoas A, Even-Hernandez P, Burel A, Mriadec C, Artzner F, Bouceba T, Minard P, Dujardin E, Marchi V (2020) Hybrid gold nanoparticlequantum dot self-assembled nanostructures driven by complementary artificial proteins

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Lipotropics are substances that prevent an abnormal accumulation of fat in the liver

LRK and MM constructed the double and triple deletion strains