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Downstream costs : All reported downstream costs are based on assumptions of population trends (i.e., incidence, prevalence, and mortality rates), time horizon, resource utilization, patient compliance, health care patterns, market trends (i.e., rates of intervention uptake or trends in current programs in place in the province), and estimates of funding and prices

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co-administration of pyridoxine has been shown to reduce the blood levels of phenobarbital and phenytoin, possibly diminishing their anticonvulsant efficacy

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