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Tirzepatide 50% to 57% of participants in the 10 mg and 15 mg groups achieved 20% or more body weight reduction at week 72

Results vary based on individual response and adherence

Surprisingly, CD38 bound to the plasma membrane has its catalytic site located on the extracellular domain of the cell, which poses theoretical difficulties for understanding how CD38 generates cADPR in the cytoplasm, where it should be available to interact with calcium channels

MIC injections are cheaper and better tolerated but should not be presented as an equivalent alternative only as an option for patients who cannot or will not use GLP-1 therapy, with expectations set accordingly

It remains an investigational compound