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Tu J, Zhang X, Zhu Y, Dai Y, Li N, Yang F, et al

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Metformin has been recommended by the American Diabetes Association and the European Association for the Study of Diabetes as the initial drug for the treatment of patients with T2D in 2012 (Inzucchi et al., 2012)

Lactobacillus , particularly Lactobacillus murinus , whose abundance increases significantly following metformin treatment, has been shown to mitigate intestinal barrier dysfunction and lipid peroxidation [24, 28]