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It also interacts with the AKT/mTOR pathway involved in cell survival and growth, and with MAPK/ERK signaling linked to proliferation and differentiation
Recent studies have further supported this view and additionally identified lactylation modification of LCP1
Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks
Following medium change, cells were treated as indicated
Nature 456 , 259263 (2008)
