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NRF2 in lung cancer chemotherapy resistance The in vitro studies of human cancer cell lines A549, NCI-H292 and LC-AI cells showed that knockdown of NRF2 inhibited cell proliferation and reduced resistance to cisplatin.19,23 Silencing of NRF2 with shRNA or siRNA resulted in inhibition of proliferation of A549 cells with mutated KEAP1 and increased NRF2 levels.24 Furthermore, silencing of NRF2 by RNAi sufficiently reversed resistance to cisplatin in NSCLC cells and improved the sensitivity of A549 to doxorubicin and etoposide.14 Although KEAP1 mutation often increases ARE gene targets by increasing the availability of NRF2, it has also been shown to directly enhance the induction of PPAR and confer chemoresistance.25 A recent study identified the increased NRF2 and target gene levels with accelerated tumor growth, tumor cell proliferation and migration in lung cancer cell lines A549 and H460 with KEAP1 loss-of-function mutations.26 In addition, NRF2 inhibition with ML385 could inhibit the proliferation of tumor cells with KEAP1 mutation.26 Therefore, all these growth advantages arising from overactivation of NRF2 lead to poor outcomes in lung cancer and make NRF2 an independent prognostic factor for survival analysis of lung cancer patients.27 Interestingly, Satoh et al

This suggests that moderate activation of HIF-1 during bone defect repair may promote osteoangiogenic regeneration

If you have a skin sensitivity, you can peel the mango while stabilizing it with gloves or a towel to avoid direct contact

doi: 10.1021/bi972791w

Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia