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Description
Due to structural similarities in the active sites of 5-lipoxygenase-activating protein (FLAP), leukotriene C 4 synthase and prostaglandin E synthase, substrates for each enzyme can compete with one another and modulate synthetic activity [22]
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DOI: 10.1016/j.pbi.2023.102444
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells
In contrast, Nrf2/Trsp double-KO mice show a massive increase in ROS and severe anemia (95)
