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6,7,11,15 In the absence of newborn screening, these disorders pose a diagnostic challenge because of the intermittent nature of clinical symptoms and biochemical abnormalities, many of which are present only during times of physiologic distress and catabolism

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For instance, elevated GLUT3 expression is observed not only in thyroid cancer [33] and glioblastoma [34] but also across a range of aggressive tumors such as triple-negative breast cancer [35] and head and neck squamous cell carcinoma [36], where it is significantly associated with a poor prognosis for patients