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A nasal spray, on the other hand, goes in through your nose and gets absorbed by blood vessels in your nasal passages

Last Reviewed: December 17, 2025 by Jose Vazquez, LVN

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Understanding how semaglutide makes you feel underscores this point: the effects are metabolic and appetite-related, not psychoactive

Learning Objectives Review the latest data concerning patients undergoing gender-affirming hormone therapy Discuss strategies aimed at minimizing thrombotic risk, such as utilizing transdermal applications Evaluate treatment options gleaned from studies involving cisgender individuals Examine the incidence of polycythemia associated with testosterone use in gender-affirming hormone therapy, and explore treatment strategies including dose adjustment, transdermal formulations, and temporary interruptions in therapy Introduction Survey-based studies report that 0.3%-4.5% of the adult population self-identify as transgender or gender diverse, although obtaining accurate data poses methodological challenges