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However, if modified (PEGylation or ligand-functionalization), PLGA nanoparticles could escape the RES clearance, allowing longer systemic plasma half-life and accumulation in the CNS 99

Sci Rep (2018) 8(1):9513

For the majority of young males, the condition of gynecomastia resolves itself spontaneously by the time they reach 21

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ROS-induced damage to DNA, proteins, and lipids can directly lead to cell death, but it also promotes microglial activation and the release of pro-inflammatory cytokines, further exacerbating neurodegeneration (Tfilin et al., 2023)