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Lyons et al., 2018

While it is easy to understand the metabolic underpinning of SLC7A11-induced glutamine dependency (given that SLC7A11-mediated glutamate export is directly linked to glutamine metabolism), how SLC7A11 promotes glucose dependency has remained less clear (partly because SLC7A11-associated metabolism is not directly connected to glucose metabolism)

[PubMed Citation] Cigolini D, Ricci G, Zannoni M, Codogni R, De Luca M, Perfetti P, Rocca G