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One plausible explanation for the present findings is that, on average, OI are more opioid-tolerant than non-injecting participants, possibly due to changes in mu -receptor signaling arising from rapid-onset, high-dose exposure associated with injection use
[DOI] [PubMed] [Google Scholar] 74.Kandarakis S.A., Togka K.A., Doumazos L., Mylona I., Katsimpris A., Petrou P., Kymionis G
