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References Jasmer, K

In the United States, a drug development company must file for Investigational New Drug (IND) status before a FIH trial can begin, often preceded by a pre-IND meeting with the FDA

The subsequent decrease in GSH:GSSG ratio has consequences for MGO detoxification and the redox status [65], which may ultimately alter BBB permeability

Astrocytes disrupt autophagy by releasing IL-1, which suppresses AMPK/mTOR signaling, blocking autophagic flux and -syn clearance [256]

However, we found lower expression of CD69 in STR with rapamycin compared to LTR with rapamycin, including in the patient-derived CAR T cells used in the Nalm6 mice experiments (Supplementary Fig