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This vital intracellular antioxidant plays an essential role in protecting against oxidative stress , driving liver detoxification pathways , supporting robust immune function , and optimizing mitochondrial performance

The AAPS journal , 23 (1), 22

Although hypericin has been traditionally employed for various therapeutic purposes, a comprehensive assessment of its toxicological properties is essential to ensure safe administration.34 Hypericin is characterized by relatively low acute toxicity, with mild and reversible symptoms typically observed following single high-dose exposure

This indicates a zonation trend within iHLOSs with prolonged culturing

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