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Possible explanations are the reduced viability of chondrocytes, as found by Chu et al

Metabolic endotoxemia and diabetes mellitus: A systematic review
Immunometabolic regulation of vascular redox state: the role of adipose tissue

Additionally, BCL2-inhibitors have been shown to have senolytic effects in some senescent cell models 1,4

PLA 2 proteins act to hydrolyse the ester bonds of phospholipids to release free fatty acids, including arachidonic acid, a key substrate for phospholipid peroxidation 37,38
