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However, it should be stated that the bioactive compounds that are tested in these in vitro assays will not be the real metabolites that could eventually reach functional enzymes in an in vivo context providing that polyphenols are eventually metabolized before reaching target tissues

10.1016/j.jconrel.2017.05.007 148 RaymanM
Cancer risk in patients with multiple sclerosis: potential impact of disease-modifying drugs
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