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Moreover, adverse effects such as nasal irritation and epistaxis (nosebleeds) can further discourage patients from adhering to their treatment plans [5]

The danger model was first suggested in 1994, were it was first postulated that the immune system responds to substances that cause damage, rather than to those that are simply foreign (93, 94)

For example, several studies have linked the occurrence of excess protein and aggregated protein deposition with diseases

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However, future experimental and clinical studies are warranted to explore the molecular mechanisms involved in the ALAs protection against prenatal CYT-induced testicular injury