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Implicated specifically were increased angiogenesis, elevated vascular endothelial growth factor (VEGF) levels, upregulation of the early growth response (egr-1) gene, enhanced nitric oxide (NO) and NO-synthase (eNOS) stimulation, and counteraction of increased free radical formation [1]

Figure 1 depicts the flowchart of the study design

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Also, women with prolonged breastfeeding are at lower risk because of the suppression of ovulatory cycles and thus the reduction of levels of hormones (ER and PR) over time (52, 53)