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Mechanistically, copper accumulation can induce ATP depletion, which in turn activated AMP-activated protein kinase to promote HMGB1 phosphorylation and enhance its release

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The broad-spectrum anticancer potential of TB m A-Glu against GGT-overexpressing cancer cells was further demonstrated through subsequent investigations, including OVCAR-5 and murine 4T1 cancer cells (Supplementary Fig

Based on the evolutionary relationship, the TmGsts were divided into at least 4 classes, including the Ure2, the GTT1, EF1B, and Zeta