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This is confirmed through the studies on both the effects of IGF-1 in the skin as well as the study on genetic mutations affecting Insulin Receptors on keratinocytes

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Kerr , Cumali Keskin , Mohammad Keykhaei , Yousef Saleh Khader , Himanshu Khajuria , Mohammad Khalafi , Nauman Khalid , Mohammad Khammarnia , Asaduzzaman Khan , Atif A

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147 Overexpression of miR-144-3p could downregulate the GSH/GSSG ratio, increase the levels of ROS, Fe 2+ , and ACSL4, promote ferroptosis and thus reduce the metastasis of osteosarcoma cells, while high expression of ZIB1 plays the opposite role, 147 indicating that miR-144-3p and its downstream ZIB1 are involved in the development and metastasis of osteosarcoma mainly by interfering with iron metabolism and redox homeostasis