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The HD-GYP domain, cyclic di-GMP signaling, and bacterial virulence to plants
Given the positive effects in multiple animal models of aging and neurodegeneration, including models of AD, clinical trials for rapamycin in AD are underway (NCT04200911, NCT04629495)
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4BG and Supplementary Data S8)
Consequently, innovative strategies are required to either bypass or transiently disrupt the BBB to improve drug delivery and therapeutic efficacy in GB treatment
