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No adverse effects were reported and a significant reduction in liver tests (specifically transaminases and gamma-glutamyltranspeptidase -GGT-), with many cases of bio humoral parameters normalization, was detected in all treated patients, even several months after treatment interruption

Additional experiments using isoform-specific inhibitors, eNOS phosphorylation analysis, genetic knockdown, VEGFR2 neutralization, and rescue designs would be needed to define the pathway more precisely

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