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\n\n\n\n Preclinical studies have reported no significant toxic, mutagenic, or carcinogenic effects at research amounts in short- to medium-term rodent studies

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The disease is spontaneous, is associated with a relatively low frequency within the colony and lesions that wax and wane, making it an interesting observation but not a model that is readily amenable to experimental manipulation

Nature 649 , 487495 (2026)

Liver X receptor agonist therapy prevents diffuse alveolar hemorrhage in murine lupus by repolarizing macrophages