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An update on PUG-REST: RESTful interface for programmatic access to PubChem

Fensterseifer et al., 2015[36]
Compounds like (-)-agelasidine A and prodigiosin upregulate UPR components (PERK, IRE1) and pro-apoptotic proteins (CHOP, Bax, caspases) while downregulating anti-apoptotic Bcl-2, synergistically activating intrinsic and extrinsic apoptotic pathwayseffects reversible by the ERS inhibitor 4-PBA [94, 118]

In addition, pathways related to hormone stimulus, oxidative stress and endoplasmic reticulum were also enriched (Fig

Acta 967 , 64 (2017) J
