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Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

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Biotin injections are also involved in the metabolism of carbohydrates, fats, and proteins, benefiting overall health and wellness

The intake evaluation then confirms whether the chosen combination is clinically appropriate and sets the injection schedule and cycle structure for each compound