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Environmental factors, which vary significantly between African and Western populations, also contribute to differences in treatment response
14 In a meta-analysis of 4 observational studies with 28,000 patients, the risk of non-melanoma skin cancer was significantly higher among patients exposed to these drugs

Thus, the two trigger regions that flank each end of the miRNA-binding site interact with the RBEs of both ZSWIM8 protomers to form a cross-brace securing the AGO2miRNA complex inside the E3 ligase clamp

Prev Nutr Food Sci 27(3):282298